BoJack Horseman

Original characters in an original anthropomorphic world; no established characters to swap.

Features strong female characters like Diane and Princess Carolyn, but they are written with real flaws, not as flawless girlbosses, and men aren't mocked as a message.

• Diane struggles with depression and her own failings
• Princess Carolyn faces career and personal setbacks

Todd Chavez is a central character whose asexuality becomes a major, explicitly explored storyline over multiple seasons.

• Todd's coming out as asexual and exploring what that means
• Asexual community meetups Todd attends
• Various LGBTQ+ supporting characters

Diverse cast of characters in a fictional animal-human world; fits the setting naturally without overriding lore.

• Vietnamese-American character Diane Nguyen
• Latino character Todd Chavez

The show tackles depression, addiction, sexual misconduct, and mental health thoughtfully; messaging is folded into character drama but occasionally turns pointed, especially around #MeToo themes.

• Storyline addressing a beloved actor's sexual misconduct and public reckoning
• Episodes exploring abortion and gun control with satirical commentary

BoJack's self-destructive, narcissistic behavior is critiqued, and the show examines harm done by powerful men, but it's framed as personal accountability rather than a blanket anti-masculinity message.

• BoJack's repeated harm to women examined critically
• Hank Hippopopalous storyline mirroring real-world predator cover-ups

Wholly original series with no source material.